- Omega-3 supplements may help you meet your needs if you don’t get enough through food.
- Check the dose, source and form of omega-3s to make sure they are high-quality and absorbable.
- Look for products that have independent testing and transparent labeling.
Omega-3s are polyunsaturated fats best known for their role in heart and brain health. Research suggests they may also help regulate inflammation, support eye health and potentially reduce the risk of chronic conditions such as heart disease, arthritis and cognitive decline.
The omega-3s most strongly linked to these benefits are EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), which are found primarily in fatty fish and algae-based foods. However, getting enough of these essential fatty acids from food alone can be challenging—especially if you don’t eat fish regularly or rely mostly on plant-based omega-3s, which come in the form of ALA and convert poorly in the body. While a food-first approach is always the goal, supplements can be a helpful option when intake falls short.
The tricky part? Knowing which omega-3 supplements are actually worth buying. To help break it down, we spoke with pharmacist Jessica Beal-Stahl, Pharm.D., about how to choose a high-quality omega-3 supplement.
1. Check the EPA + DHA Amount (Not Just “Fish Oil”)
“The health benefits of omega-3 supplementation are primarily driven by the fatty acids EPA and DHA, not by the total amount of fish oil listed on the label,” says Beal-Stahl.
Many products prominently advertise “1,000 mg fish oil” on the front of the bottle, but that number often includes other fats that don’t provide the same well-studied benefits. Instead, flip the bottle over and check the Supplement Facts panel for the specific amounts of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) per serving.
Products that clearly list EPA and DHA content per serving offer “far more clinical relevance than those that emphasize total oil weight alone,” Beal-Stahl explains. That’s because EPA and DHA are the omega-3s most closely linked to researched health benefits.
For general adult health, many experts recommend aiming for about 250 to 500 mg of combined EPA and DHA per day, though needs may vary depending on diet, health status and individual goals. In some cases, higher doses may be appropriate under the guidance of a health care professional.
2. Consider the Source
“The source of omega-3s matters,” says Beal-Stahl. EPA and DHA can come from fish oil, krill oil, algal oil or fish roe. “No single source is ‘best,’ and the right choice depends on dietary preferences, tolerability and sustainability considerations,” she explains.
For example, algal oil is a plant-based option derived from algae that may appeal to vegetarians or those who avoid seafood, while fish and krill oils are more traditional sources of EPA and DHA. Research suggests that when taken at similar doses, both algal and fish oil supplements can raise EPA and DHA levels in the body to a comparable degree. So no matter which one you choose, you can still experience the health benefits of an omega-3 supplement.
3. Check the Form for Enhanced Absorption
Beyond the source, the chemical form of omega-3s can also influence how well they’re absorbed. Beal-Stahl explains that triglyceride and phospholipid forms tend to be more easily absorbed than ethyl ester forms, although all can be effective depending on dose, formulation and how they’re taken. Some research suggests that EPA and DHA may be more readily absorbed from monoacylglycerides, phospholipid and triglyceride-based forms than from ethyl ester forms, though findings have been inconsistent.
To identify the form, check the ingredient list or product description and look for terms such as:
- Triglyceride form: Triglyceride, re-esterified triglyceride (rTG)
- Monoglyceride form: Monoacylglycerides (MAG omega-3), monoglycerides, acetylated monoglycerides
- Phospholipid form: Omega-3 phospholipids, krill oil (rich in phosphatidylcholine)
- Ethyl form: Ethyl ester (EE)
Regardless of the form, Beal-Stahl says taking omega-3 supplements with a meal that contains fat can help improve absorption.
4. Look for Independent Testing and Transparent Labeling
Not all supplements are held to the same standards. Unlike prescription medications, dietary supplements are not reviewed or approved by the Food and Drug Administration before they reach consumers. Instead, manufacturers are responsible for product safety, while the FDA monitors supplements after they’re on the market.
Consumers can identify reputable omega-3 supplements by looking for independent testing and adherence to good manufacturing practices, says Beal-Stahl. Independent testing—sometimes called “third-party testing”—helps confirm that a product contains what it claims on the label, is free of harmful contaminants and meets benchmarks for purity and potency.
Several independent organizations, including ConsumerLab, NSF International and US Pharmacopeia (USP), offer voluntary testing and certification programs for dietary supplements. Products that have undergone independent testing often display a certification emblem or logo directly on the supplement label or product packaging. If you don’t see one on the bottle, check the product’s website.
Clear labeling is another important signal of quality. Products should list the exact amounts of EPA and DHA per serving and disclose the form of omega-3s used—not vague proprietary blends that lack transparency about ingredient amounts.
Should You Take an Omega-3 Supplement?
“There’s a tendency to view omega-3 supplements as a substitute for diet rather than a complement to it,” says Beal-Stahl. “Supplements are intended to support overall intake, not replace omega-3-rich foods when those are accessible.”
If you regularly eat fatty fish—such as salmon, mackerel or sardines—twice a week, you may already be meeting general intake recommendations. That said, supplements can be helpful for people who don’t consume much seafood or who may have increased needs.
Individuals taking blood-thinning medications, those with bleeding disorders or anyone preparing for surgery should speak with a health care provider before starting an omega-3 supplement, as higher doses may increase bleeding risk. People with fish or shellfish allergies, as well as those who are pregnant or breastfeeding, should also seek professional guidance to ensure appropriate product selection and dosing.
If you’re considering an omega-3 supplement to help manage cardiovascular, autoimmune or metabolic conditions, personalized guidance may be especially important. A brief conversation with a pharmacist or health care provider can help ensure omega-3 use is safe, appropriate and aligned with your individual health goals.
Our Expert Take
Omega-3 supplements can be a helpful way to fill gaps when dietary intake falls short—but not all products are created equal. What matters most is the total EPA and DHA per serving, choosing a source and form that aligns with your preferences and selecting a product with independent testing to confirm quality. When in doubt, consulting a health care professional can help you decide whether supplementation makes sense for you and how to use it safely.
