NutraBio Deep Sleep features PeptiSleep™, an AI-discovered peptide that targets the cortisol disruption causing poor sleep. Clinical trial participants gained 38 more minutes of sleep per night with major improvements in REM, deep sleep, and HRV.
NutraBio just raised the bar in sleep supplementation with Deep Sleep, a formula built around PeptiSleep™, an AI-discovered peptide ingredient from brown rice that targets receptors in the adrenal cortex above the kidneys to reduce local stress induced cortisol, a root cause of poor sleep quality. Combined with dual-release melatonin, high-dose calming amino acids, and additional sleep-supporting compounds, Deep Sleep addresses what most sleep aids miss: the entire sleep cycle, not just helping you fall asleep.
A Sleep Aid Powered by PeptiSleep™ Hydrolyzed Rice Protein Containing Bioactive Peptides from Nuritas!
If you’ve ever taken melatonin only to wake up at 3 AM unable to fall back asleep, or felt groggy the next morning, you’re experiencing exactly what PeptiSleep was designed to solve. Discovered through Nuritas’ AI-powered peptide discovery platform, PeptiSleep works differently than traditional sleep aids by modulating stress hormones that disrupt sleep architecture.
We recently discussed this technology in depth with Nuritas CEO Dr. Nora Khaldi on Episode #198 of The PricePlow Podcast. Deep Sleep combines cutting-edge peptide science with proven sleep-supporting ingredients to create a comprehensive formula for active individuals who need quality recovery overnight.
We get into what we know below, but first, check prices and availability sign up for PricePlow’s news alerts so you don’t miss future announcements, studies, and flavor drops:
NutraBio Deep Sleep – Deals and Price Drop Alerts
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NutraBio Deep Sleep Ingredients
NutraBio Deep Sleep delivers 11.98 grams per serving with the following active ingredients, starting with PeptiSleep, the main reason we’re so excited:
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PeptiSleep™ (Brown Rice Protein Hydrolysate) – 250mg
PeptiSleep™ is the centerpiece of this formula and addresses what most sleep aids miss: elevated cortisol. Discovered through Nuritas’ AI platform from over 9 million plant peptides, these specific bioactive peptide sequences from brown rice target the hormonal disruption.
Here’s the mechanism: melatonin and cortisol are counterregulatory hormones that govern the sleep-wake cycle. As melatonin rises to signal rest, cortisol falls to allow the body to recover. By morning, cortisol naturally rises to wake you up while melatonin declines. When this diurnal rhythm is dysregulated, stress lingers and sleep suffers.
Elevated cortisol from the adrenal cortex can keep the body stuck in a state of nighttime alertness, driven in part by overactive orexin signaling — the system that promotes wakefulness and arousal. By antagonizing peripheral orexin, PeptiSleep’s bioactive peptide network calms this stress pathway at its source, supporting healthier cortisol rhythms and more restorative sleep without disrupting your natural wake-up cycle or causing grogginess.
The soon-to-be-published clinical trial investigating the effects of a 250mg dose of PeptiSleep (the dose in Deep Sleep) on sleep quality using both subjective clinically validated questionnaires and objective biometric data from Oura wearables:
- A difference of 12 minutes of REM sleep between groups (memory consolidation and emotional processing)
- A difference of 13 minutes of deep sleep between groups (physical recovery and immune function)
- A difference of 38 minutes of total sleep on average between groups
- 32% increase in Heart Rate Variability over the study duration (a key recovery and stress adaptation marker)
- Improvements across all four domains of the Leeds Sleep Evaluation Questionnaire: ease of getting to sleep, perceived sleep quality, ease of awakening, and behavior following wakefulness
PeptiSleep manages nighttime cortisol through orexin receptors, delivering 25 extra minutes of deep and REM sleep plus improved heart rate variability. Consumer testing shows 74% purchase interest and 25% premium willingness.
What makes these results interesting: PeptiSleep improved the entire sleep cycle, not just sleep onset. Participants fell asleep easier, stayed asleep longer, spent more time in restorative sleep stages, and woke feeling refreshed without morning grogginess.
This is fundamentally different from single-mechanism sleep aids. By managing the stress hormone disrupting your sleep architecture, PeptiSleep enables the deep recovery sleep that active individuals need for performance and health.
For more on how Nuritas’ AI technology discovered PeptiSleep and the science behind their peptide platform, check out Episode #198 of The PricePlow Podcast with CEO Dr. Nora Khaldi.
There’s a lot more coming with PeptiSleep, so stay tuned… but NutraBio is an early adopter, and if you want to try the novel peptide ingredient in a powerful formula, this is one to get.
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L-Glycine – 5g
Glycine is a non-essential amino acid that functions as both an inhibitory neurotransmitter and an NMDA receptor co-agonist in the central nervous system.[1] Through its dual receptor activity, glycine exerts calming effects while supporting cognitive function during waking hours.[2]
The sleep-promoting mechanism centers on thermoregulation. Glycine activates NMDA receptors in the suprachiasmatic nucleus, triggering peripheral vasodilation that lowers core body temperature and signals sleep onset.[1] Clinical studies at 3 grams demonstrate improved subjective sleep quality and reduced daytime fatigue in sleep-restricted individuals.[3] At 5 grams, glycine provides substantial support for both sleep architecture and recovery, with the added benefit of serving as the primary building block for collagen synthesis during overnight tissue repair.
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Taurine – 2g
Taurine is a sulfur-containing amino acid concentrated in metabolically active tissues, where it functions as a cellular osmolyte, regulating hydration and maintaining cell integrity during recovery.[4] This osmotic pressure regulation becomes important during overnight repair processes when cells undergo restoration and volume changes.
At the mitochondrial level, taurine supports energy metabolism and helps buffer oxidative stress generated during the day’s activities.[5] Taurine modulates calcium signaling in muscle tissue, which affects both cellular recovery processes and the transition into restorative sleep states.
The 2-gram dose provides substantial support for these cellular functions without stimulation, making it well-suited for nighttime use alongside the formula’s GABAergic and relaxation-promoting ingredients.
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GABA (Gamma-Aminobutyric Acid) – 750mg
GABA (gamma-aminobutyric acid) is a non-proteinogenic amino acid that functions as the primary inhibitory neurotransmitter in the central nervous system, where roughly 60-75% of all synapses are GABAergic.[6] While debate exists regarding oral GABA’s ability to cross the blood-brain barrier in significant amounts, research suggests it exerts beneficial effects through peripheral mechanisms and the gut-brain axis.[7]
GABA modulates stress responses by acting on GABA receptors in peripheral tissues and the enteric nervous system, reducing stress signaling that interferes with sleep onset.[6] Clinical studies demonstrate that GABA intake can reduce psychological stress markers and support relaxation without sedation.[7]
The 750mg dose provides substantial support for the formula’s fast-acting relaxation component, helping quiet mental activity that prevents sleep onset while working synergistically with L-theanine and other calming agents in the formula.[8] And on the note of theanine, that’s what we have next:
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L-Theanine – 200mg
L-Theanine is an amino acid from tea leaves that crosses the blood-brain barrier to modulate neurotransmitter activity. The primary effect is increased alpha wave generation, creating relaxed alertness without sedation.[9]
At the molecular level, theanine acts as a glutamate analog, binding to NMDA, AMPA, and kainate receptors to modulate excitatory signaling.[10] This glutamate antagonism calms neural activity while maintaining cognitive function. Theanine also increases brain GABA, dopamine, and serotonin levels through indirect mechanisms.[11]
Clinical trials at 200mg demonstrate reduced heart rate and cortisol responses to acute stress.[12] For sleep, theanine works through anxiolysis rather than sedation, addressing stress-driven sleep disruption.[13] Research shows synergistic effects with GABA, decreasing sleep latency and improving NREM sleep beyond either compound alone.[8]
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Lactium (Hydrolyzed Milk Protein) – 150mg
Lactium is a hydrolyzed milk protein ingredient containing bioactive peptides, specifically alpha-casozepine, derived from bovine αS1-casein.[14] These peptides interact with GABAA receptors to support relaxation and help manage stress responses without causing sedation.[14]
Clinical research demonstrates that Lactium may help reduce cortisol responses to stress, making it a complementary mechanism to PeptiSleep’s cortisol-targeting action.[15] In a consumer study across three countries, participants taking 300mg of Lactium daily for one month reported satisfaction rates of 70-90%, with significant improvements in both stress levels and sleep quality.[15]
Research using actigraphy measurements showed that Lactium significantly increased sleep efficiency after continuous use, with more pronounced effects appearing after four weeks compared to two weeks.[16] The 150mg dose in Deep Sleep matches clinically studied amounts and works synergistically with the formula’s other stress-modulating ingredients.
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Apigenin (Chamomile Seed Extract) – 50mg
Apigenin is a flavonoid from chamomile with sedative and mood-supporting effects demonstrated through multiple clinical mechanisms. While early research suggested benzodiazepine receptor binding, detailed electrophysiological studies reveal a more sophisticated action: apigenin functions primarily as an NMDA receptor antagonist, reducing glutamatergic excitation and network hyperactivity.[17]
This glutamate-dampening mechanism accounts for apigenin’s sedative properties better than GABA receptor modulation.[18] Animal studies show apigenin reduces stress-related alterations in neurotransmitter systems while supporting BDNF (brain-derived neurotrophic factor) levels in the hippocampus, linking it to both immediate calming effects and neurological resilience.[19] The 50mg dose provides gentle sleep support while contributing antioxidant and neuroprotective effects that complement the formula’s multi-pathway approach to restorative sleep.
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Melatonin (Dual-Release: 2mg Immediate + 1mg from Melotime Sustained) – 3mg Total
Melatonin is a hormone that regulates the sleep-wake cycle by signaling darkness to the brain.[20] Natural melatonin release triggers physiological changes that prepare you for sleep, including reduced core body temperature and decreased alertness.
Deep Sleep uses a dual-release system: 2mg immediate-release for fast sleep onset, plus 1mg sustained-release (Melotime) for continuous overnight support. This addresses melatonin’s primary limitation: standard forms help you fall asleep but wear off quickly, contributing to middle-of-the-night awakenings.
Meta-analyses show melatonin significantly reduces sleep onset latency and increases total sleep time, with dose-response curves showing optimal efficacy at 3-5mg daily.[20][21] The 3mg total dose represents the moderate standard: enough to support circadian rhythm without grogginess, while extended-release maintains levels through overnight recovery.
Combined with PeptiSleep’s cortisol-targeting mechanism, this dual-release approach provides comprehensive support across the entire sleep cycle. And finally, it’s time for some mineral support:
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Magnesium (as Di-Magnesium Malate) (Albion) – 210mg
Magnesium functions as a natural calcium antagonist in the nervous system, blocking NMDA receptors and modulating neurotransmitter activity that influences both sleep quality and muscle relaxation.[22] Through this mechanism, magnesium helps calm neural excitation and supports the transition into restorative sleep states.
The di-magnesium malate form combines magnesium with malic acid, an intermediate in the Krebs cycle that supports cellular energy production.[23] This pairing delivers both immediate relaxation support and metabolic benefits during overnight recovery processes.
PeptiSleep uses brown rice peptides at 250mg to target cortisol for better sleep quality without melatonin’s grogginess. Addresses widespread sleep problems affecting one-third of adults with improvements measurable on wearable trackers.
Albion’s chelated minerals demonstrate superior bioavailability compared to cheaper oxide or sulfate forms, maximizing absorption and utilization. At 210mg (50% DV), this dose provides meaningful magnesium support without overshooting daily requirements, working synergistically with the formula’s other GABAergic and stress-modulating ingredients to support complete sleep architecture.
Flavors Available
NutraBio Deep Sleep launched in three flavor options (Lemon Lavender, Passion Fruit Chamomile, Citrus Honey), but a full up-to-date-list is below:
Each flavor incorporates botanicals that complement the relaxation theme — lavender, chamomile, and honey are all traditionally associated with calming effects, making the consumption experience itself part of the wind-down ritual.
How to Use
Dosing: Mix 1 scoop with 8-10 ounces of water approximately 30 minutes before bedtime.
Timing: The 30-minute window allows the fast-acting ingredients (GABA, theanine, immediate-release melatonin) to begin working while giving PeptiSleep time to engage its cortisol-suppressing mechanism before you lie down.
Duration: Deep Sleep is non-habit forming and safe for nightly use. However, due to the formula’s potency, NutraBio recommends cycling the product and avoiding long-term continuous use.
Nuritas uses artificial intelligence to discover peptide ingredients that couldn’t exist without AI. PeptiStrong® boosts muscle recovery by 144%. PeptiSleep™ adds 38 minutes of sleep per night. Both backed by clinical trials.
Important notes: Don’t use this product with alcohol, while driving, or operating machinery. Discontinue use two weeks before surgery, and don’t combine with corticosteroids.
Stacks Well With NutraBio Growth Peptides!
Looking for a stacking idea to push the peptide power even stronger? Then check out NutraBio Growth Peptides. This muscle accelerator features PeptiStrong, another AI-discovered Nuritas peptide ingredient. PeptiStrong targets muscle protein synthesis through mTOR activation and myostatin suppression.
Together, you’re covering both sides of recovery: quality sleep for systemic restoration (Deep Sleep) and targeted muscle-building signaling (Growth Peptides).
Who It’s For
Deep Sleep is designed for:
- Athletes and fitness enthusiasts who need overnight recovery support to maintain training intensity and frequency
- Active individuals with demanding lifestyles who struggle with stress-related sleep disruption and need to maximize limited sleep time
- Anyone experiencing poor sleep quality despite getting adequate sleep duration, including middle-of-the-night awakenings or feeling unrested upon waking
- People who’ve tried melatonin with mixed results and need a more comprehensive approach that addresses cortisol dysregulation, not just sleep onset
Conclusion: AI-Discovered Sleep Science You Can Feel
Nora Khaldi, founder and CEO of Nuritas, discusses AI-powered peptide discovery, clinical validation, and the science behind PeptiStrong, PeptiSleep, PeptiYouth, and PeptiControl on Episode #198 of the PricePlow Podcast.
What sets Deep Sleep apart is the strategic combination of PeptiSleep’s cortisol-targeting mechanism with dual-release melatonin and high-dose calming amino acids. You’re not just getting help falling asleep. You’re addressing the hormonal disruption that prevents quality sleep across all stages.
The forthcoming PeptiSleep clinical data is very exciting: 38 additional minutes of sleep, improvements in both deep and REM stages, and a 32% boost in heart rate variability. These aren’t just numbers, they’re measurable improvements in the recovery processes that happen during sleep.
If you’ve struggled with sleep supplements that either don’t work or leave you feeling groggy, Deep Sleep’s approach is worth trying. The formula addresses sleep through multiple complementary pathways, with AI-discovered peptide technology at its core.
For more on the science behind Nuritas’ peptide discovery platform and how AI is changing supplement innovation, check out our introduction to Nuritas and our recent podcast with CEO Nora Khaldi.
NutraBio Deep Sleep – Deals and Price Drop Alerts
Get Price Alerts
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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.
Posts are sponsored in part by the retailers and/or brands listed on this page.
