A study published in Cureus Journal of Medical Science shows that Pycnogenol from Horphag Research (Switzerland) can significantly relieve the symptoms of lipedema, reduce body fat and improve self-esteem associated with the condition.
According to Horphag, lipedema is a chronic, often misunderstood condition that affects about 400 million women globally. It causes an abnormal and painful buildup of fat—usually in the legs, hips and buttocks—and is frequently mistaken for obesity or lymphedema.
The double-blind, placebo-controlled study included 100 women aged 18 to 40 diagnosed with lipedema and aimed to evaluate the effectiveness of Pycnogenol in managing the condition.
The key finds of the study include a 29 percent reduction in symptoms by day 60; significant relief across all reported symptoms and important improvements in the most common lipidemia problems—swelling of the legs, heavy legs, tenderness and bruising; an 8 percent reduction in body fat by day 60; the women reported an improvement in satisfaction with leg appearance and quality of life; and no adverse side effects.
According to the company, Pycnogenol’s benefits for lipedema stem from its antioxidant and anti-inflammatory properties, which help strengthen blood vessel walls, improve microcirculation and support lymphatic flow.
“The lack of validated, accessible treatment options for women with lipedema often leaves them searching for alternatives that can meaningfully improve daily comfort and mobility,” said natural physician and author Dr. Fred Pescatore. “What makes these findings important is that Pycnogenol demonstrated measurable improvements in symptoms including pain and tenderness relief, body composition and emotional well-being. Patients with lipedema now have a safe, natural option that may help fill a long-standing treatment gap.”
For more information, visit www.pycnogenol.com.
