NNB Nutrition’s Longevity Platform combines four powerful ingredients — Puremidine (spermidine), BioNMN (NMN), MitoPrime (L-ergothioneine), and GlucoVantage (dihydroberberine) — to target “youth span” through cellular recycling, energy restoration, and mitochondrial protection.
The conversation around aging has shifted. We’re no longer just talking about adding years to life, we’re focused on adding life to those years. Industry pioneer Shawn Wells captures this evolution perfectly: the concept of “youth span” has replaced health span as our primary motivator. When we look at our peers, we don’t just want to be healthy, we want to feel vibrant, look better, perform better, and maintain the energy that defines youth.
Youth Span: The Real Longevity Target at NNB Nutrition
NNB Nutrition’s Longevity Platform addresses this desire through a synergistic combination of ingredients that target the fundamental mechanisms of aging. By combining Puremidine (spermidine), BioNMN (NMN), MitoPrime (L-ergothioneine), and GlucoVantage (dihydroberberine), this platform tackles aging from multiple angles: cellular recycling, energy metabolism, mitochondrial protection, and glycation control.
The youth span science of each ingredient is discussed below. But before we dig into the details, be sure to be signed up for our NNB Nutrition news alerts below, since they have a massive year planned:
Subscribe to PricePlow’s Newsletter and Alerts on These Topics
-
Spermidine (Puremidine): The Cellular Recycling Catalyst
Spermidine stands out as what researchers call a “longevity elixir”: a compound that mimics the benefits of caloric restriction without requiring actual food restriction.[1] This naturally-occurring polyamine has emerged as one of the most interesting anti-aging compounds, with new research continuing to strengthen its position.
The Autophagy Connection
Spermidine’s primary mechanism involves activating autophagy, which is your body’s cellular recycling system. Think of autophagy as your cells’ cleanup crew, removing damaged components and maintaining optimal function. Spermidine triggers this process by inhibiting specific enzymes called histone acetyltransferases (HATs), leading to changes in gene expression that promote cellular renewal.[2]
Beyond basic autophagy, spermidine serves as the essential substrate for a unique protein modification called eIF5A hypusination. This process controls the synthesis of TFEB, a master regulator that orchestrates both autophagy and the creation of new cellular recycling machinery.[3]
Clinical Evidence for Youth Span Extension
Recent population research provides compelling evidence for spermidine’s benefits. A 2022 analysis of U.S. dietary data found that higher spermidine consumption correlates with reduced cardiovascular disease and improved longevity markers across hundreds of thousands of people.[4]
Even more striking, a 2025 study found that each 1mg of dietary spermidine intake correlated with a 0.075-year reduction in biological age, suggesting that 11-12mg daily could effectively make you a year younger on cellular aging markers.[5] The effect was partially mediated through IGF-1 pathways, accounting for over 11% of the biological age deceleration.
Cognitive Protection That Protein Restriction Can’t Match
A groundbreaking 2025 study revealed that while both spermidine and protein restriction can protect against aging, they work through independent mechanisms. Crucially, protein restriction failed to protect against age-related memory decline, while spermidine reversed it.[6] This positions spermidine as essential for maintaining cognitive youth span.
Clinical trials in elderly adults with dementia showed that 3.3mg daily supplementation improved cognitive test scores, with high-dose groups showing 50% greater gains than low-dose groups. Benefits included improvements in verbal fluency, memory, and overall cognitive function.
Dosing and Application
Puremidine delivers the clinically validated 3.3mg dose in a pure, synthetic form that’s free from the allergens and contaminants found in wheat-derived alternatives. This GRAS-approved ingredient achieves therapeutic benefits in a single serving, making it practical for long-term daily supplementation.
You can learn more in our article titled “What is SPERMIDINE?! Meet the Latest Longevity Ingredient“.
-
NMN (BioNMN): The NAD+ Restoration Powerhouse
If spermidine is the recycling catalyst, NMN (nicotinamide mononucleotide) is the energy restoration engineer. This NAD+ precursor addresses one of aging’s most fundamental problems: the progressive decline in cellular energy production.
The NAD+ Crisis of Aging
NAD+ (nicotinamide adenine dinucleotide) is essential for hundreds of cellular processes, from energy metabolism to DNA repair to liver detoxification. Unfortunately, NAD+ levels can decrease by up to 50% between ages 40 and 60. NMN directly addresses this decline through the salvage pathway, where it’s converted to NAD+ by specific enzymes called NMNATs.[7]
This NAD+ restoration activates sirtuins (a family of proteins that act as cellular conductors), orchestrating everything from metabolism to stress response. Think of sirtuins as quality control managers that need NAD+ as their fuel to function. Without adequate NAD+, these critical regulators simply can’t do their job.
Human Clinical Validation
Unlike many longevity compounds that rely solely on animal data, NMN has substantial human clinical evidence. A 2022 trial with 80 middle-aged adults demonstrated dose-dependent increases in blood NAD+ levels, with 600mg daily providing optimal elevation that plateaued at higher doses.[8]
The clinical benefits extend beyond biomarkers:
- Enhanced insulin sensitivity in prediabetic women with just 250mg daily
- Improved aerobic capacity and walking distance
- Better muscle strength in older adults
- Reduced biological age scores on validated aging calculators
Formulation Innovation with BioNMN: Beadlet Technology Available
BioNMN showcases NNB’s formulation expertise through their beadlet technology. As NNB emphasizes, they “can make almost anything with beadlets, delayed release or with liposomal technology.” This capability ensures optimal absorption and stability of this sensitive molecule, addressing the bioavailability challenges that have historically limited NAD+ precursor supplementation.
The standard effective dose ranges from 300-600mg daily, with benefits observed as early as 4 weeks and optimizing at 8-12 weeks of consistent use.
The story goes deep on this one. You can read more about it in our articles, “NMN, FDA, and the Supplement Industry’s Fight Against Pharma“ and “BioNMN: A Reliable NMN Supplement Ingredient“. The long story short is that NMN is a legal dietary supplement, as it has an acknowledged NDIN (New Dietary Ingredient Notification) from the FDA.
-
L-Ergothioneine (MitoPrime): The Mitochondrial Guardian
While spermidine recycles and NMN energizes, L-ergothioneine provides targeted protection where aging hits hardest: the mitochondria. This unique sulfur-containing amino acid has earned designation as a “longevity vitamin” from renowned scientist Bruce Ames.
An Evolutionary Testament to Importance
Humans cannot synthesize our own ergothioneine, so we must obtain it through diet or supplementation. Yet our bodies evolved a highly specific transporter system (OCTN1) dedicated exclusively to its uptake and retention.[9] This evolutionary investment suggests profound biological importance.
Three major scientific reviews now support Ergothioneine as a “longevity vitamin” essential for healthy aging! MitoPrime by NNB Nutrition delivers pharmaceutical-grade L-Ergothioneine to protect your cells from oxidative damage and support cognitive health.
Ergothioneine concentrates in tissues most vulnerable to oxidative stress: blood, liver, brain, and especially mitochondria. Unlike typical antioxidants that are rapidly excreted, ergothioneine is retained with minimal urinary loss (less than 4%), continuing to accumulate for weeks after supplementation.
Direct Mitochondrial Protection
Ergothioneine’s primary benefit lies in its mitochondrial accumulation, where it reduces hydrogen peroxide production and protects mitochondrial DNA from oxidative damage.[10] This protection extends to nuclear DNA as well, with cells lacking the ergothioneine transporter showing increased genetic damage.[11]
Beyond direct antioxidant effects, ergothioneine activates the NRF2 pathway, which is your cells’ master antioxidant defense system. This creates a cascading protective effect that goes far beyond simple free radical scavenging.
Biomarkers of Youth Span
Low blood ergothioneine levels correlate with multiple aging markers:
- Increased frailty in elderly populations[12]
- Accelerated cognitive decline[13]
- Higher cardiovascular disease mortality
NNB Nutrition introduces MitoPrime and SalidroPure – two innovative ingredients that work at the cellular level to deliver clean, sustainable energy without crashes.
In fact, ergothioneine was identified as the metabolite most significantly associated with reduced morbidity and mortality in coronary artery disease studies.[14]
MitoPrime Advantages
MitoPrime delivers pure L-isomer ergothioneine at 5-30mg doses, matching the levels used in human pharmacokinetic studies. This 100% pure, fermented form ensures optimal bioavailability and tissue accumulation. The compound’s remarkable safety profile, with an LD50 over 2,000mg/kg in mice, allows for confident long-term supplementation.
You can read our long-form article titled “Ergothioneine: The Immunity and Energy Protector“ for more information on this fascinating ingredient, whose history is thought to go back billions of years!
-
Dihydroberberine (GlucoVantage): The Anti-Glycation Shield
While the primary longevity trio addresses cellular recycling, energy, and protection, dihydroberberine adds a crucial fourth dimension: glycation control. This enhanced form of berberine offers approximately 5-fold better bioavailability than standard berberine, achieving superior metabolic outcomes with just 400-600mg daily.
The Glycation-Aging Connection
GlucoVantage from NNB Nutrition, featuring dihydroberberine, isn’t just for managing healthy blood sugar. It supports better body composition, boosts energy, and may lower the risk of chronic illnesses. But today, we focus on its ability to combat Advanced Glycation Endproducts.
Glycation, the process where sugars bind to proteins, creates advanced glycation end-products (AGEs) that accumulate with age. These AGEs cause tissue stiffness, inflammation, and mitochondrial dysfunction. The GlucoVantage patent specifically notes that berberine metabolite administration “may lower glycation (e.g., measured by HbA1c levels) which may provide anti-aging properties.”[15]
Metabolic Youth Through AMPK
Dihydroberberine activates AMPK (AMP-activated protein kinase) by creating controlled mitochondrial stress through complex I inhibition.[16] AMPK acts as a cellular energy sensor that, when activated, triggers responses that mimic caloric restriction, thereby improving insulin sensitivity, enhancing fat oxidation, and activating autophagy pathways.
The compound also restores GLP-1 secretion, the same pathway targeted by popular weight-loss medications, but through natural cellular mechanisms rather than pharmaceutical intervention.[17]
While GlucoVantage isn’t in the primary trio of youth span ingredients from NNB Nutrition, we thought it wise to include it as well, thanks simply to the battle against AGEs. You canl earn more in our article, “Dihydroberberine: A Better Berberine“.
The Synergistic Youth Span Platform
The true power of NNB’s Longevity Platform emerges through synergy. Each ingredient addresses different aspects of aging while supporting the others:
GlucoVantage® dihydroberberine redefines metabolic health by boosting GLP-1 levels by 95% in new research. Its superior bioavailability and multi-faceted benefits—like better body composition, lipid profiles, and oxidative stress reduction—position it as a groundbreaking natural alternative to GLP-1 drugs.
- Complementary Autophagy Activation: Spermidine triggers autophagy through HAT inhibition while dihydroberberine activates it via AMPK. This means two independent pathways working toward the same cellular renewal goal.
- Wide-Scale Mitochondrial Support: NMN provides the NAD+ fuel for mitochondrial function, ergothioneine protects against mitochondrial damage, and dihydroberberine creates beneficial mitochondrial hormesis that strengthens these cellular powerhouses.
- Multi-Level DNA Protection: Ergothioneine directly shields DNA from oxidative damage, NMN enhances DNA repair through PARP activation, and spermidine maintains telomere length through enhanced cellular recycling.
- Metabolic Optimization: Dihydroberberine improves glucose metabolism and insulin sensitivity, NMN enhances cellular energy production, and spermidine supports metabolic flexibility through improved mitochondrial function.
Implementing the Youth Span Protocol
For optimal results, consider this evidence-based approach:
NNB Nutrition’s mimetic supplements hack your biology: MitoBurn (L-BAIBA) triggers exercise signals at rest, GlucoVantage (dihydroberberine) activates GLP-1 pathways naturally, and Puremidine (spermidine) mimics fasting’s cellular cleanup. The science is wild.
Morning:
- BioNMN: 300-600mg before breakfast
- Puremidine: 3.3mg with breakfast
- GlucoVantage: 100-200mg with breakfast
Evening:
- MitoPrime: 10-30mg with dinner
- GlucoVantage: 100-200mg with dinner
This timing maximizes the natural circadian rhythms of cellular repair and metabolic processes while ensuring optimal absorption of each ingredient.
The Future of Youth Span Extension
NNB Nutrition’s Longevity Platform represents more than just a collection of ingredients… it’s a systems-level approach to maintaining youth span through targeted cellular interventions. By addressing autophagy, energy metabolism, mitochondrial protection, and glycation simultaneously, this platform tackles aging at its fundamental roots.
The formulation expertise NNB brings, from beadlet technology to delayed release and liposomal delivery systems, ensures these powerful ingredients reach their cellular targets effectively. This technological advantage, combined with the synergistic mechanisms of action, positions the platform as a cornerstone of modern longevity intervention.
Shawn Wells and Dustin Elliott of NNB Nutrition join the PricePlow Podcast for Episode #152 to discuss innovative ingredients that capture ongoing trends like GLP-1 and MPS. We also get into Dustin’s trip to China, NNB’s participation in XPO NRG with MitoPrime, and Shawn’s psychedelic experiences and his post-trip supplement stack.
As research continues to unveil the mechanisms of aging, one thing becomes clear: maintaining youth span requires a multi-faceted approach. We of course haven’t even touched on diet, sunshine, blue light avoidance, sleep, and the other factors that are so important.
But in terms of supplementation, NNB Nutrition has the stack for brands to build around. Through cellular recycling with spermidine, energy restoration with NMN, mitochondrial protection with ergothioneine, and glycation control with dihydroberberine, NNB’s platform offers a scientifically validated path to not just living longer, but living younger.
The goal isn’t just to add years to your life. It’s to ensure those years are filled with the vitality, appearance, and performance that define youth. That’s the promise of the youth span revolution, and it’s a promise backed by compelling science.
Learn more about NNB Nutrition in our article, “The NNB Nutrition Story: Supplement Ingredient Solutions for the New Decade“.
