- A study finds that adverse experiences in life are associated with higher dementia risk.
- Depression appears to play a significant mediating role in the connection to dementia.
- Addressing mental health through therapy and trauma support may help reduce dementia risk.
When you think about protecting your brain health as you age, you probably consider things like crossword puzzles, a Mediterranean diet or regular exercise. But new research suggests there’s another powerful—and often overlooked—factor that could influence your dementia risk: your mental health history and past traumatic experiences.
Dementia affects millions of people worldwide, and that number is only expected to grow. In the U.S. alone, the prevalence of dementia is projected to rise to 88 million by 2050, making it a leading cause of disability and death among older adults. While we know that factors like heart health and lifestyle habits play a role in brain aging, scientists are increasingly interested in how psychological stress across your lifetime might affect your cognitive future.
Researchers from China wanted to explore whether difficult experiences in childhood and adulthood—and the depression that often follows—might be connected to dementia and stroke risk later in life. They analyzed data from a large, long-term study of Chinese adults and published their findings in JAMA Network Open. What they discovered could change how we think about brain health prevention—and it starts with taking your mental health seriously.
How Was This Study Conducted?
The researchers used data from the China Health and Retirement Longitudinal Study, a nationally representative study that tracks the health of Chinese adults aged 45 and older. For this analysis, they followed 11,601 participants for nearly five years on average.
The team assessed two types of difficult life experiences. Adverse childhood experiences (ACEs) included 12 indicators of trauma that occurred during childhood, such as household dysfunction, family death or disability and social difficulties. Adverse adulthood experiences (AAEs) covered five types of adult trauma, including the death of a child, lifetime discrimination, being confined to bed, being hospitalized for a month or longer and leaving a job due to health problems.
Participants were categorized based on how many adverse experiences they reported in each category. The researchers also assessed depression using a standardized questionnaire. They then tracked who developed dementia or had a stroke during the follow-up period, while accounting for other factors like age, sex, education, smoking, drinking, sleep, diabetes and heart disease.
What Did the Study Find?
The results revealed some striking connections between life stress and brain health. Both childhood and adult adverse experiences were significantly linked to higher dementia risk. Specifically, each additional adverse childhood experience was associated with an 11% higher risk of developing dementia, while each additional adverse adulthood experience was linked to a 23% higher risk.
The findings were even more dramatic when researchers looked at people with multiple adverse experiences. Those who reported four or more childhood adverse experiences had a 64% higher risk of dementia compared to those with none. And people with four or more adult adverse experiences had a 141% higher risk.
Perhaps most notably, people who experienced high levels of trauma in both childhood and adulthood faced the greatest risk—a 228% higher chance of developing dementia compared to those with low exposure in both life stages.
Here’s where therapy comes into the picture: depression appears to be a key pathway connecting these adverse experiences to brain health outcomes. The researchers found that depression mediated about 34% of the link between childhood trauma and dementia, and about 21% of the connection between adult trauma and dementia.
The study does have some limitations worth noting. The diagnosis of dementia wasn’t made by neurologists but rather through cognitive assessments and self-reported diagnoses. Information about adverse experiences relied on participants’ memories, which could introduce some recall bias. And because this was an observational study, the researchers can’t definitively say that adverse experiences cause dementia—only that they’re associated with higher risk.
How Does This Apply to Real Life?
These findings suggest that protecting your brain health isn’t just about physical factors—your emotional well-being matters too. The good news is that unlike your past experiences, depression is something you can address right now. There are even some steps you can take to lower your dementia risk bit by bit.
Here are some steps you might consider:
- Prioritize your mental health. If you’ve experienced trauma or are struggling with depression, consider making an appointment with a therapist or counselor. Since depression appears to be a significant pathway between adverse experiences and dementia risk, treating it could potentially help protect your brain.
- Build a support system. Strong social connections can help buffer the effects of stress and support mental health, and they can actually lower dementia risk as you get older. Stay connected with friends, family or community groups.
- Try eating the MIND diet. If you’re especially concerned about your dementia risk, eating brain-healthy foods and an overall balanced diet can help. The MIND diet is a version of the Mediterranean diet that has been modified to include principles of the heart-healthy DASH diet. Some of our favorite MIND diet recipes are included in this simple week of meals for a healthy brain.
- Get active. If you’re not already exercising, it’s OK to start small. Moving your body more often—whether that means going for a swim, taking a walk in the neighborhood or dancing around the kitchen—can help lower your dementia risk.
Our Expert Take
A new study in JAMA Network Open found that adverse experiences throughout life—from childhood trauma to adult hardships—are associated with increased dementia and stroke risk, with depression playing a significant mediating role. The findings highlight an often-overlooked aspect of brain health: your mental and emotional well-being. While you can’t change your past, addressing depression and seeking support for trauma through therapy may help protect your cognitive health as you age. If you’ve experienced significant life stressors or are struggling with depression, consider talking to a mental health professional—it could be one of the most important appointments you make for your brain.
